After initial treatment AZD1152 datasheet with ciclosporin, based on trough concentrations, and enteric-coated mycophenolate sodium (1440 mg/day, orally), corticosteroids (>= 5 mg/day prednisolone or equivalent, orally), and basiliximab induction (20 mg, intravenously, on day 0 [2 h before transplantation], and on day 4), 300 (60%) patients were randomly assigned at 4.5 months in a 1:1 ratio

to undergo calcineurin-inhibitor elimination (everolimus-based regimen that was based on trough concentrations [6-10 ng/mL] and enteric-coated mycophenolate sodium [1440 mg/day] with corticosteroids), or continue standard ciclosporin-based treatment. Randomisation was done by use of a central, validated system that automated the random assignment of treatment groups to randomisation numbers. The primary objective was to show better renal function (glomerular filtration rate [GFR]; Nankivell formula) with the calcineurin-inhibitor-free everolimus regimen at 12 months after transplantation. Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00154310.

Findings 118 (76%) of 155 everolimus-treated patients and 117 (81%) of 145 cic_losporin-treated patients completed treatment with study drug up to 12 months after transplantation. see more At this timepoint, the

everolimus regimen was associated with a significant improvement in GFR versus the ciclosporin regimen (71.8 mL/min per 1.73 m(2) vs 61.9 mL/min per 1.73 m(2), respectively; mean difference 9.8 mL/min per 1.73 m(2), 95% CI -12.2 to -7.5). Rates of biopsy-proven acute rejection were higher in the everolimus group than in the ciclosporin group after randomisation (15 [10%] of 154 vs five [3%] of 146; p=0.036), but similar for the

full study period (23 [15%] vs 22 [15%]). Compared with the ciclosporin regimen, higher mean lipid concentrations, slightly increased urinary protein excretion, and lower haemoglobin concentrations were noted with the everolimus regimen; thrombocytopenia, aphthous stomatitis, and diarrhoea also occurred Baf-A1 in vitro more often in the everolimus group. A higher incidence of hyperuricaemia was noted with ciclosporin.

Interpretation Early elimination of calcineurin inhibitor by use of everolimus-based immunosuppression improved renal function at 12 months while maintaining efficacy and safety, indicating that this strategy may facilitate improved long-term outcomes in selected patients.”
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