Blood samples were collected before and at several time points after intake. Whole-genome gene expression profiles of PBMCs were examined before and 6 h after intake of the PUFA and SFA shakes. In addition, ex vivo incubation of human PBMCs with different fatty acids was performed.
Results: Whole-genome expression AZD5153 mw analysis showed distinct differences between PUFA and SFA consumption. PUFA intake decreased the expression of genes in liver X receptor signaling, whereas SFA intake increased the expression of these genes. PUFA intake also increased the expression of genes related to cellular stress responses. MUFA intake had an intermediate effect
on several genes. Ex vivo experiments showed a direct effect of free fatty acids on PBMC gene expression.
Conclusion: This study showed that PBMCs can reveal fatty acid-specific gene expression profiles in young
healthy men after the consumption of different fatty acids, as evidenced by the opposite effects of PUFA and SFA intakes on the expression of genes involved in liver X receptor signaling. This trial was registered at www.clinicaltrials.gov as NCT01000194. Am J Clin Nutr 2010;91:208-17.”
“The natural frequency of nanotubes with consideration of surface effects is studied using the nonlocal Timoshenko beam theory. This theory with long-range interactions revealing the nanoscale effect can be applied to study the vibration behavior of nanostructures. When the nonlocal effect is neglected in the analysis, www.selleckchem.com/products/acy-738.html the result is identical to the previous study which used a modified Timoshenko beam theory. According to the analysis, Stem Cell Compound Library the application of the modified Timoshenko beam theory for nanotubes would lead to an underprediction of the natural frequency. (C) 2010 American Institute of Physics. [doi:10.1063/1.3503853]“
“We evaluated the feasibility and incidence of hematological toxicity in a series of 39 breast cancer patients treated at our Institute with doxorubicin plus cyclophosphamide (AC) followed by docetaxel, using prophylactic G-CSF (Pegfilgrastim). We
prescribed G-CSF as secondary prophylaxis during the AC regimen and as primary prophylaxis during treatment with docetaxel. For the AC treatment, we recorded 6 cases of grade III (15.3%) and one case of grade IV (2.5%) neutropenia; we found one case of Grade IV anemia. For the docetaxel regimen, we registered one case of Grade IV (2.5%) neutropenia and three cases of Grade III leukopoenia without neutropenia. No patients experienced cardiac symptoms or baseline LVEF rate decrease. All patients concluded the programmed chemotherapy. Our experience shows the safety of docetaxel in combination with anthracyclines and the efficacy of prophylaxis with G-CSF in breast cancer adjuvant chemotherapy.”
“Background: Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women.