Four animals received a sham operation. After selleckchem left lung transplantation and contralateral lung exclusion, hemodynamics and blood gases were monitored
for 6 hours; tissue samples were taken at the end of the experiments.
RESULTS: All animals survived the transplantation procedure. Base solution and Custodiol-N preserved lungs (Groups IT and III) showed graft function similar to that of LPD-preserved lungs (Group I), showing a trend toward improved values. Custodiol-N with dextran (Group IV) led to a significant reduction of mean pulmonary arterial pressure (20 +/- 2 vs 28 +/- 3 mm Hg, p < 0.01) and pulmonary vascular resistance (410 +/- 51 vs 588 +/- 83 dyne/s/cm(5), p < 0.01), and oxygenation ratio was significantly higher (536 +/- 52 vs 313 +/- 107 mm Hg at 6 hours, p < 0.01) and PCO2 values were significantly lower (51 +/- 9 vs 77 +/- 5 mm Hg at 6 hours, p < 0.01) at 6 hours compared
with LPD (Group I). Custodiol-N (Groups 11 to IV) showed a trend toward a lower wet/dry ratio and reduced oxidative stress; in the presence of dextran (Group IV), the difference was again statistically significant, when compared with LPD (Group I).
CONCLUSIONS: Custodiol-N solution is a new alternative preservation solution for lung transplantation that offers significantly superior protection compared with LPD when dextran 40 is added. J Heart Lung Transplant 2012;31:310-7 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.”
“Emphysematous pyelonephritis learn more (EPN) is a severe and complicated renal infection characterized by gas formation within the infected kidney and its surrounding tissues. Early
diagnosis with a high index of suspicion and aggressive treatment are important for improving outcome. Bilateral involvement is rare, and surgical ABT-263 order intervention is usually required because of its high mortality rate. A literature review found that EPN has rarely been noted in chronic dialysis patients, and those who show bilateral EPN have demonstrated no survival at all until now. Herein, we presented a 51-year-old diabetic uremic woman who developed right emphysematous pyelitis initially and then progressed to bilateral EPN when hospitalized. Percutaneous drainage (PCD) with simultaneous antibiotic therapy successfully eradicated her renal infection. In this study, all reported cases of EPN in chronic dialysis patients were also reviewed.”
“Morphine-based analgesia is effective but can compromise donor safety. We investigated whether continuous infusion of local anesthetics (CILA) can provide sufficient pain control and reduce morbidity related to opiate analgesics after hand-assisted retroperitoneoscopic (HARS) live donor nephrectomy. Forty consecutive live kidney donors underwent HARS and were treated with the ON-Q system providing CILA with 0.