Hepatology 1999, 29 (3) : 946–953 PubMedCrossRef 77 Kekule AS, L

Hepatology 1999, 29 (3) : 946–953.PubMedCrossRef 77. Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH: Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 1993, 361 (6414) : 742–745.PubMedCrossRef 78. Doria M, Klein N, Lucito R, Schneider RJ: The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J 1995, 14 (19) : 4747–4757.PubMed LBH589 in vivo 79. Klein NP, Schneider RJ: Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling

to Ras. Mol Cell Biol 1997, 17 (11) : 6427–6436.PubMed 80. Hsu T, Moroy T, Etiemble J, Louise A, Trepo C, Tiollais P, Buendia MA: Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell 1988, 55 (4) : 627–635.PubMedCrossRef 81. Takada S, Gotoh Y, Hayashi S, Yoshida M, Koike K: Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues. J Virol 1990, 64 (2) : 822–828.PubMed

82. Buetow KH, Sheffield VC, Zhu M, Zhou T, Shen FM, Hino O, Smith M, McMahon BJ, Lanier AP, London WT, et al.: Selleckchem MK-2206 Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas. Proc Natl Acad Sci USA 1992, 89 (20) : 9622–9626.PubMedCrossRef 83. Urano Y, Watanabe K, Lin CC, Hino O, Tamaoki T: Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line. Cancer Res 1991, 51 (5) : 1460–1464.PubMed 84. Natoli G, Avantaggiati ML, Chirillo P, Costanzo A, Artini M, NF-��B inhibitor Balsano C, Levrero M: Induction of

the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX. Mol Cell Biol 1994, 14 (2) : 989–998.PubMed 85. Natoli G, Avantaggiati ML, Chirillo P, Puri PL, Ianni A, Balsano C, Levrero M: Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus GPX6 transactivator pX. Oncogene 1994, 9 (10) : 2837–2843.PubMed 86. Benn J, Su F, Doria M, Schneider RJ: Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol 1996, 70 (8) : 4978–4985.PubMed 87. Huang SN, Chisari FV: Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 1995, 21 (3) : 620–626.PubMed 88. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang W: Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004, 25 (10) : 2023–2032.PubMedCrossRef 89. Shinmura K, Yokota J: The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal 2001, 3 (4) : 597–609.

Comments are closed.