\n\nDesign: An individual diet model was specifically developed for each adult participating in the French national INCA (Enquete Individuelle et Nationale sur les Consommations Alimentaires) dietary survey (n = 1171). Starting from each individual weekly food intake (observed diets), an isocaloric modeled diet was designed by linear programming to simultaneously meet the French Vorinostat mw nutrient recommendations for

32 nutrients while deviating the least from the observed food intake. Modeled diets were paired with observed diets for statistical comparison.\n\nResults: A new nutritionally adequate diet was obtained for each individual. In half the modeled diets, <5 of the foods usually consumed were replaced. The amount of foods selected in the modeled diets varied from individual to individual, and this variability followed that found in observed diets. Fruit, vegetables, grains, legumes, dried fruit, unsalted nuts, fresh dairy products, and fish were increased in modeled

diets. Fatty fish and walnuts were added to each modeled diet. In contrast, red meats, deli meats, cheese, mixed INK1197 dishes, and salted snacks were decreased. Sweets were also decreased but to a lesser extent.\n\nConclusions: This new individual diet modeling approach offers the possibility of translating nutrient recommendations into realistic food choices for all individuals from a representative population. The results showed that nutrient needs can be fulfilled in many different ways, depending on initial individual food patterns.

Am J Clin Nutr 2010:91:421-30.”
“BACKGROUND: Advanced-stage osteonecrosis and a large area of necrotic bone are known risk factors for failure of transtrochanteric rotational osteotomy of the hip in patients with osteonecrosis. The purpose of this study was to determine whether there are other risk factors for failure of this osteotomy.\n\nMETHODS: One hundred and five patients (113 hips) underwent an anterior transtrochanteric rotational osteotomy for the treatment of femoral head osteonecrosis and were followed for a mean of 51.3 months AZD6738 solubility dmso postoperatively. Radiographic failure was defined as secondary collapse or osteoarthritic change. Multivariate analysis was performed to assess factors associated with secondary collapse and osteophyte formation. The Kaplan-Meier product-limit method was used to estimate survival.\n\nRESULTS: Secondary collapse occurred in twenty-seven hips (24%), and fourteen hips (12%) were converted to a total hip arthroplasty. At the time of the most recent follow-up, the hip scores according to the system of Merle d’Aubigne et al. ranged from 6 to 18 points (mean, 15.8 points). Multivariate analysis showed that the stage of the necrosis (III or greater) (hazard ratio = 3.28; 95% confidence interval = 1.49 to 7.24), age of the patient (forty years or older) (hazard ratio = 1.08; 95% confidence interval = 1.02 to 1.