All rights reserved.”
“Knowledge of demographic and social correlates of problem gambling among men and women in general population samples is limited. Such research is important for identifying individuals who may become problem gamblers. The current research

used a gender-stratified analysis using logistic regression models in a nationally representative sample to identify correlates of problem gambling among men and women. AG-14699 Data were from the Canadian Community Health Survey Cycle 1.2 (CCHS 1.2; data collected in 2002; response rate 77%). The 12-month prevalence of problem gambling among men and women who endorsed gambling in the past year was 4.9% and 2.7%, respectively. For women, increased odds of problem gambling was associated with middle age, middle to low levels of income, a high school diploma or less, being never-married, higher levels of life stress, and negative coping abilities. For men, being aged 70 or greater decreased the odds of problem gambling, while being separated, widowed, or divorced, lower levels of social support, and negative coping abilities increased the odds of problem gambling. These findings have important GPCR & G Protein inhibitor public health implications for identifying men and women who may be more

likely to become problem gamblers in the general population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Sirtuin 2 (SIRT2), a sirtuin family protein, is a tubulin deacetylase. Recent studies have indicated that SIRT2 plays a key role in programmed necrosis, and the SIRT2 inhibitor AGK2 can decrease the cell death both in a cellular model of Parkinson’s disease and in an animal model of myocardial ischemia-reperfusion. However, there has been little information regarding

the role of SIRT2 in microglial survival and functions, which play critical roles in multiple neurological disorders. Our current study found that AGK2 at 10 mu M – a widely used AGK2 concentration – can induce both late-stage apoptosis and necrosis, as well as a decrease in the intracellular ATP levels of microglial BV2 cells. Our study also showed that both the AGK2-induced cell death and the AGK2-induced ATP decline VX-661 purchase are mediated by poly(ADP-ribose) polymerase (PARP) activation. Collectively, our study has provided the first evidence suggesting a significant role of SIRT2 in the basal survival of microglia, as well as a mechanism accounting for the effects of SIRT2 on intracellular ATP levels. (c) 2013 Elsevier Ireland Ltd. All rights reserved.”
“This study identified empirically derived subtypes of gamblers based on the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnostic criteria for pathological gambling disorder (PGD). Data from the gamblers (n = 5644) who participated in the 2007 British Gambling Prevalence Survey (BGPS) were analysed using latent class analysis. Common socio-demographic correlates of PGD were subsequently assessed across the classes.