Methods: Twenty patients with histopathologically confirmed rectal cancer (Stage II-III) were enrolled in the study. Radiotherapy of 50 Gy was delivered in 25 fractions of 2 Gy, one fraction/day,

five fractions/week, for 5 weeks. Oxaliplatin 55 mg/m(2) was administered intravenously for 60 minutes on Day 1 every 2 weeks, and tegafur-uracil 350 mg/m(2) was given orally everyday during the whole radiotherapy selleckchem course, including holidays. Surgery was scheduled 6 weeks after completion of the preoperative chemoradiotherapy. The primary endpoint was to determine the pathologic complete response (pCR) rate after this neoadjuvant chemoradiotherapy. The secondary endpoint was to determine the treatment-related toxicity profile, local control, DFS,

OS, and time to metastasis.

Results: All patients underwent a complete course of preoperative chemoradiotherapy. There was no local recurrence during the study period. The complete resection rate was 20/20 (100%) and the close resection margin rate was 3/20 (15%). The pCR rate was 8/20 (40%). During chemoradiotherapy, the most frequent toxicity was diarrhea 9/20 (45% of patients, grade 2 in 3/20, 15%). There were Rabusertib research buy no grade 3 or higher hematologic or non-hematologic events or treatment-related deaths.

The 3-year OS and DFS rates were 94.1% and 78.6%, respectively.

Conclusion: Preoperative chemoradiotherapy with oxaliplatin and tegafur-uracil was well-tolerated and achieved an excellent pCR in our patients with locally advanced mid-to-lower rectal cancer. Copyright (C) 2013 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.”
“Globally, focus has been given on the development of neem oil based agrochemical formulations by replacing synthetic agro chemical based products. One of the main inert components in liquid agrochemical formulation is petroleum based solvent which has been replaced by water, by solubilizing the neem KU-57788 order oil which can act as a pesticide. These water based microemulsions may have the benefit of natural pesticide along with replacement of highly volatile petroleum solvents which create number of problems in agrochemical formulations like irritation to the eyes at the time of manufacturing and applications, phytotoxicity to the plants, etc. In this study we have demonstrated the feasibility of constructing pseudo ternary phase diagrams which are fully diluted with water.