Table 11 Markers of catabolism and bone status Marker N Group Day   p-level       0 CHIR-99021 purchase 7 28     BUN (mg/dl) 11 KA-L 16.0 ± 5.3 15.3 ± 4.9 15.6 ± 5.1 Group 0.89   12 KA-H 16.1 ± 3.3 16.6 ± 3.9 16.6 ± 3.6 Time 0.70   12 CrM 16.4 ± 3.2 15.7 ± 2.7 16.1 ± 4.7 G x T 0.75 Creatinine 11 KA-L 1.04 ± 0.08 1.08 ± 0.11 1.13 ± 0.10† Group 0.07 (mg/dl) 12 KA-H 1.07 ± 0.14 1.23 ± 0.18†* 1.26 ± 0.13†* Time 0.001   12 CrM 1.11 ± 0.19 1.28 ± 0.20†* 1.23 ± 0.15†* G x T 0.03 BUN:CRN Ratio 11 KA-L 15.5 ± 5.1 14.5 ± 5.6 14.1 ± 5.6 Group 0.83   12 KA-H 15.1 ± 3.4 13.7 ± 3.4 13.3 ± 3.4

Time 0.001   12 CrM 15.2 ± 3.7 12.4 ± 2.6 13.2 ± 3.8 G x T 0.24 AST (U/L) 11 KA-L 25.4 ± 9.6 26.5 ± 8.4 29.5 ± 12.9 Group 0.62   12 KA-H 27.3 ± 10.5 25.6 ± 8.3 32.0 ± 12.0 Time 0.02   12 CrM 24.9 ± 7.9 23.8 ± 7.5 26.3 ± 7.8 G x T 0.70 ALT (U/L) 11 KA-L 21.5 ± 11.2 23.5 ± 14.2 28.7 ± 19.4 Group 0.50   12 KA-H 24.1 ± 15.6 22.3 ± 12.2 27.3 ± 9.1 Time 0.05   12 CrM 21.3 ± 7.34 18.0 ± 4.2 21.3 ± 5.5 G x T 0.48 Total Protein (g/dl) 11 KA-L 7.4 ± 0.6 7.4 ± 0.4 7.4 ± 0.4 Group 0.87   12 KA-H 7.3 ± 0.3 7.3 ± 0.3 7.3 ± 0.2 Time 0.88   12 CrM 7.3 ± 0.2 7.3 ± 0.2 7.4 ± 0.3 G x T 0.84 TBIL (mg/dl) 11 KA-L 0.84 ± 0.7 0.75 ± 0.3 0.76 ± 0.3 Group 0.60   12 KA-H Torin 1 molecular weight 0.88 ± 0.5 0.89 ± 0.5 0.77 ± 0.4 Time 0.90   12 CrM 0.63 ± 0.2 0.71 ± 0.2 0.77 ± 0.2 G x T 0.26 Bone Mineral 11 KA-L 2,517 ± 404 2,503 ± 409 2,505 ± 398 Group 0.59 Content (g) 12 KA-H 2,632 ± 457 2,604 ± 466 2,615 ± 456 Time 0.49   12 CrM 2,446 ± 344 2,456 ± 0.2 2,441 ± 351 G x T 0.66 Albumin (g/dl) 11 KA-L 4.80 ± 0.3 4.81 ± 0.4 4.81 ± 0.2 Group 0.95   12 KA-H 4.83 ± 0.2 4.74 ± 0.2 4.78 ± 0.1 Time 0.73 else   12 CrM 4.82 ± 0.2

4.80 ± 364 4.79 ± 0.2 G x T 0.89 Globulin (g/dl) 11 KA-L 2.60 ± 0.4 2.63 ± 0.3 2.55 ± 0.3 Group 0.90   12 KA-H 2.56 ± 0.3 2.58 ± 0.2 2.52 ± 0.3 Time 0.85   12 CrM 2.55 ± 0.3 2.54 ± 0.2 2.62 ± 0.3 G x T 0.42 Alb:Glob Ratio 11 KA-L 1.88 ± 0.3 1.85 ± 0.2 1.90 ± 0.2 Group 0.98   12 KA-H 1.90 ± 0.1 1.86 ± 0.2 1.91 ± 0.1 Time 0.70   12 CrM 1.88 ± 0.2 1.90 ± 0.2 1.84 ± 0.2 G x T 0.45 Calcium (mg/dl) 11 KA-L 9.87 ± 0.5 9.85 ± 0.5 9.76 ± 0.4 Group 0.42   12 KA-H 9.83 ± 0.2 9.81 ± 0.4 9.84 ± 0.2 Time 0.51   12 CrM 9.77 ± 0.3 9.63 ± 0.4 9.67 ± 0.3 G x T 0.76 ALK (U/L) 11 KA-L 82.0 ± 16.4 84.1 ± 20.5 83.9 ± 17.0 Group 0.88   12 KA-H 81.1 ± 29.7 83.8 ± 30.3 87.1 ± 27.6 Time 0.29   12 CrM 78.9 ± 20.7 80.6 ± 26.4 78.8 ± 23.1 G x T 0.65 Values are means ± standard deviations.