The mitochondria are rich in CoQ10 and therefore training also increases the CoQ10 content in heart and muscle [11]. Training also increases the biosynthesis of CoQ10 and therefore there is also a higher requirement for ingredients that are needed for the CoQ10 biosynthesis. On the other hand, the mitochondria normally do not reach the CoQ10

SBI-0206965 molecular weight saturation level [12]. This practically means that at the actual concentrations of CoQ10 in these membranes the velocity of the respiratory complexes is not the maximal one. There is still capacity to increase the CoQ10 content in the mitochondria, and this could explain the increase of maximal oxygen uptake (VO2-max) by CoQ10 supplementation [9]. Heavy physical training leads to a decrease in plasma CoQ10. Plasma CoQ10 is inversely correlated to the intensity of training or exercise. The muscle CoQ10 content is linear dependent on the content of Type I, oxidative muscle fibers [13]. In a study by Fiorella and Bargossi [14], the CoQ10

Plasma level increased less after supplementation when the BTSA1 purchase athletes exercised heavily. It seems that the CoQ10 in the plasma is immediately absorbed by the exercising muscle. Exercise may stimulate the muscular uptake of CoQ10 from the plasma. CoQ10 dosage for athletes In animal models, administration of CoQ10 has shown an increase in Rapamycin solubility dmso CoQ10 concentrations in organs, in particular the heart and muscle. In these studies it was also shown that CoQ10 supplementation also increased Vitamin E content in heart muscle and liver [15]. In humans, a dosage of 120 mg CoQ10 given to athletes was unable to increase the muscle CoQ10 content [16]. To increase the human muscle CoQ10 content, it is necessary to increase the CoQ10 plasma to a greater extent over a longer period of time, so that the muscle tissues have enough time to absorb the CoQ10 from the plasma. Higher dosages of 200–300 mg CoQ10 3-mercaptopyruvate sulfurtransferase or more of Ubiquinol per day over a 4–12 week period is needed to increase muscle CoQ10 content. In one trial, 200 mg CoQ10 supplementation for 14 days lead to a trend of in increased

muscle CoQ10 content [17]. Based on these observations, 100 mg CoQ10 per day for athletes may be insufficient to achieve any enhancement in performance. Indeed, earlier studies were likely unsuccessful because of inadequate dosing, resulting in suboptimal CoQ10 plasma levels. In an earlier Italian study, a dosage of 100 mg CoQ10 per day only increased the plasma level to a value of 1.34 μg/ml [18], which is too low to achieve any effects for athletes. In a later Italian study the same 100 mg dose raised the CoQ10 plasma level to 2.23 μg/ml. After 2 months of CoQ10 supplementation, greater exertion was required to induce exhaustion and overall performance improved. Another study found the dose of 100 mg CoQ10 exerted no effect, but a 300 mg dosage of CoQ10 and raising plasma level to 3.