These are useful INCB024360 cell line features that the practitioner can use to assess menorrhagia at the time of an initial visit. Philipp et al. [16], also reported on the importance of flooding, not as confirmation of menorrhagia, but as a predictor of a bleeding disorder. The investigators administered a 12-page questionnaire of bleeding symptoms. Symptoms with high predictive values for laboratory haemostatic abnormalities were combined and used as single variables to calculate sensitivity, specificity and positive and negative predictive values to develop a short screening tool to identify females for testing

and evaluation for a bleeding disorder. The screening tool was considered to be positive if one of the following four criteria was met: 1  Duration of menses greater than or equal to 7 days and flooding or impairment of daily activities with most periods. The screening tool alone had a sensitivity of 82% for bleeding disorders. Although the results would not be available at an initial visit, adding a pictorial blood assessment chart score

>100 increased the sensitivity of the screening tool to 95%. It has also been recognized that menorrhagia is not the only reproductive tract manifestation of a bleeding disorder. In a survey of 102 women with Romidepsin in vivo VWD conducted by the United States Centers for Disease Control and Prevention (CDC), the next most common reproductive tract abnormality that women with VWD reported after menorrhagia was a history of ovarian cysts (52% among cases vs. 22% among controls).

Although ovulation is not normally accompanied by any significant amount of bleeding, in women with VWD or other bleeding disorders, ovulation can result in bleeding into the follicular sac, the peritoneum, Thiamet G the broad ligament and the retroperitoneum. In a case series of patients with VWD, Silwer found the incidence of haemorrhagic ovarian cysts in women to be 6.8% [17]. Haemorrhagic ovarian cysts have also been reported in women with afibrinogenemia, factor X deficiency, factor XIII deficiency, platelet defects or in women who are haemophilia carriers [18]. Acutely, surgery, tranexamic acid and clotting factor replacement have been used to manage haemorrhagic ovarian cysts [19–21]. Oral contraceptives, which suppress ovulation and may increase clotting factors, have been used to prevent recurrences [21–23]. In the same CDC survey, 30% of women with VWD reported a history of endometriosis compared to 13% of controls [24].