Proc Int Conf Intell Syst Mol Biol 1998, 6:175–182.PubMed 15. Petersen TN, Brunak S, von Heijne G, Nielsen H: SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 2011, 8:785–786.PubMedCrossRef 16. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S: MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum Wortmannin manufacturer parsimony methods. Mol Biol Evol 2011, 28:2731–2739.PubMedCrossRef 17. Frawley ER, Kranz RG: CcsBA is a cytochrome c synthetase that also functions in heme transport. Proc Natl Acad Sci U S A 2009, 106:10201–10206.PubMedCrossRef see more 18. Beckett CS, Loughman JA, Karberg KA, Donato

GM, Goldman WE, Kranz RG: Four genes are required for the system II cytochrome c biogenesis pathway in Bordetella pertussis , a unique bacterial model. Mol Microbiol 2000, 38:465–481.PubMedCrossRef 19. Kranz RG, Richard-Fogal C, Taylor JS, Frawley ER: Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control. Microbiol Mol Biol Rev 2009, 73:510–528.PubMedCrossRef 20. Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den selleck products Camp

HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M: Molecular mechanism of anaerobic ammonium about oxidation. Nature 2011, 479:127–130.PubMedCrossRef 21. Jones DT, Taylor WR, Thornton JM: The rapid generation of mutation data matrices from protein sequences. Comp Appl Biosci: CABIOS 1992, 8:275–282.PubMed 22. Stewart EJ, Katzen F, Beckwith J: Six

conserved cysteines of the membrane protein DsbD are required for the transfer of electrons from the cytoplasm to the periplasm of Escherichia coli . EMBO J 1999, 18:5963–5971.PubMedCrossRef 23. Porat A, Cho SH, Beckwith J: The unusual transmembrane electron transporter DsbD and its homologues: a bacterial family of disulfide reductases. Res Microbiol 2004, 155:617–622.PubMedCrossRef 24. Ito K, Inaba K: The disulfide bond formation (Dsb) system. Curr Opin Struct Biol 2008, 18:450–458.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contribution CF, JWAA and MSMJ conceived of the study. DRS sequenced and analyzed the genomic data of Brocadia. CF built the datasets and ran homologue searches. DRS, JR, JTMK, and HJMOC assisted in bioinformatics analysis and data interpretation. CF, JWAA, and MSMJ wrote the manuscript with input from all co-authors. All authors read and approved the final manuscript.”
“Background Salmonella enterica subspecies enterica serovar Typhimurium is one of the most prevalent serovars isolated from ill humans in Mexico, with swine being the most common food-animal reservoir [1].