Study design. Forty patients diagnosed with TMJ OA and 20 healthy control subjects were included in this study. Synovial fluid was collected in the OA group and the healthy group at baseline. The OA patients were randomly divided into 2 groups (20 patients for each group): One group received 5 injections of SH, and the other received 5 injections of physiologic saline solution in the upper joint space at weekly intervals. Synovial fluid was collected before and after treatment. Urokinase-type PA (uPA), soluble uPA receptor

(suPAR) and PA inhibitor 1 (PAI-1) levels in synovial fluid were quantified by enzyme-linked immunosorbent assay.

Results. The OA patients had see more significantly higher uPA activity and levels of uPA (median 80.01 ng/L), suPAR (median 7.54 ng/L), and PAI-1 (median 54.9 ng/mL) than the healthy control subjects (median 20.47 ng/L uPA, 2.34 ng/L suPAR, and 19.9 ng/mL PAI-1; (P < .05). The uPA activity and levels of uPA, suPAR, and PAI-1 were significantly decreased after SH injections in TMJs of OA patients (P < .05), and there was no difference after saline injection. Visual analog pain score reduction correlated with changes in uPA and

uPAR levels as well as uPA activity.

Conclusion. The effects of SH on PA system provide new insight into a possible underlying mechanism by which SH alleviates pain of patients with TMJ OA. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; HSP990 solubility dmso 109: 541-547)”
“Urinary tract infections (UTI) occur frequently in older people. Unfortunately,

UTI is commonly overdiagnosed and overtreated on the basis of nonspecific clinical signs and symptoms. The diagnosis of a UTI in the older patient requires the presence of new urinary symptoms, with or without systemic symptoms. Urinalysis is commonly used to diagnose infection in this population, however, the evidence for its use is limited. There is overwhelming evidence that asymptomatic bacteriuria should not be treated. Catheter associated urinary tract infection accounts for a significant amount of hospital-associated infection. Indwelling urinary catheters Tyrosine Kinase Inhibitor Library manufacturer should be avoided where possible and alternatives sought. The use of narrow spectrum antimicrobial agents for urinary tract infection is advocated. Local guidelines are now widely used to reflect local resistance patterns and available agents. Guidelines need to be updated to reflect changes in antimicrobial prescribing and a move from broad to narrow spectrum antimicrobials.”
“We present a case of atrioventricular node reentrant tachycardia that displays spontaneously alternating antegrade and retrograde conduction via 1:2 manners. (PACE 2011; 34:e43-e46).”
“Objective.

Methods: Fifty-eight consecutive limbs in fifty-six consecutive older, sedentary

patients with insertional or midsubstance Achilles tendinosis were enrolled prospectively and underwent the procedure. Ten patients were lost to follow-up, leaving forty-eight limbs in forty-six patients available for evaluation after twenty-four months.

Results: The forty-six patients who were included in the study had AZD7762 an average age of 54 +/- 10 years with an average body mass index of 33.8 +/- 6.8 kg/m(2). Significant improvement was observed between baseline and twenty-four months in terms of the visual analog scale for overall pain intensity (6.7 +/- 2.3 versus 0.8 +/- 2.0; p < 0.001), the Short Form-36 physical score (34.3 +/- 8.0 versus 49.0 +/- 9.3; p < 0.001), the Ankle Osteoarthritis Scale pain (54.4 +/- 19.2 versus 1.9 +/- 2.7; p < 0.001) and dysfunction (62.6 +/- 21.4

versus 11.0 +/- 24.2; p < 0.001) subscale scores, and performance of a single-leg heel rise (1.9 +/- 3.0 versus 7.3 +/- 2.7 cm; p < 0.001). Significant improvement compared with baseline was observed at three or six months except in the single-leg heel rise. Improvements in terms of pain and function occurred overtwenty-four months, with the most improvement occurring in the first twelve months. At twenty-four months, maximum gastrocnemius circumference was significantly less in the involved compared with the uninvolved leg

(40.2 +/- 5.1 versus 41.2 +/- 4.8 cm; p < 0.001). The mean passive range of motion of the first PR-171 metatarsophalangeal joint decreased from 85.1 degrees +/- 25.3 degrees preoperatively Stattic to 68.1 degrees +/- 36.7 degrees (a 20% change) at six months (p = 0.03). Most patients reported no hallux weakness (57%; twenty-six of forty-six patients) and no loss of balance due to hallux weakness (76%; thirty-five of forty-six patients). Postoperative peroneal tendinitis was observed in seven patients. Complications included deep-vein thrombosis (two patients), superficial infection or delayed wound-healing (six), scar pain (four), and early disruption of the reconstruction due to a fall (one).

Conclusions: Surgical debridement of the Achilles tendon with flexor hallucis longus tendon transfer was associated with significant improvement in terms of Achilles tendon function, physical function, and pain intensity in a group of relatively inactive, older, overweight patients. When present, hallux weakness had minimal functional sequelae.”
“Background: Wants awaiting heart transplantation (HT) face the highest wait-list mortality among all children and adults listed for HT in the USA. We sought to determine the risk of death for infants <12 months old while awaiting HT in the current era, and to identify, the principle risk factors associated with wait-list mortality.

However, fibrinolysis cannot be initiated instantaneously at FMC, and PPCI is superior to fibrinolysis in reducing mortality if the extra time needed to perform PPCI instead of fibrinolysis (so-called PCI-related delay) is <120 min. During the past 10 years, the terms ‘FMC-to-PPCI delay’ and ‘PCI-related delay’ have been used in guidelines synonymously; however, a distinction should be made between the recommended FMC-to-PPCI delay and the acceptable PCI-related delay. In the future, an ideal recommendation would be to initiate reperfusion as

soon as possible, preferably within 120 min of FMC in the case of PPCI. When the expected PCI-related delay is <120 min, PPCI should be the preferred reperfusion strategy, even if the FMC-to-PPCI delay is >120 min. MK-4827 Setting up a health-care system enabling prehospital diagnosis of STEMI with field triage of patients directly to catheterization laboratories at large-volume PCI centres (bypassing local hospitals, coronary care units, emergency departments, and intensive care units) will help to increase the proportion of patients with STEMI who will

benefit from PPCI. Lassen, J. F. et al. Nat. Rev. Cardiol. 10, 41-48 (2013); published online 20 November 2012; doi:10.1038/nrcardio.2012.156″
“Background: Neurologic deterioration (ND) after acute ischemic stroke (AIS) has been shown to result in poor outcomes. ND is thought to arise from penumbral excitotoxic cell death caused in part by leukocytic infiltration. Elevated admission peripheral leukocyte levels are associated with poor outcomes in stroke selleck patients who suffer ND, but little is known about the dynamic changes that occur in leukocyte

counts around the time of ND. We sought to determine if peripheral leukocyte levels in the days surrounding ND are correlated with poor outcomes. Methods: Patients with AIS who presented to our Quizartinib nmr center within 48 hours of symptom onset between July 2008 and June 2010 were retrospectively identified by chart review and screened for ND (defined as an increase in National Institutes of Health Stroke Scale score >= 2 within a 24-hour period). Patients were excluded for steroid use during hospitalization or in the month before admission and infection within the 48 hours before or after ND. Demographics, daily leukocyte counts, and poor functional outcome (modified Rankin Scale score 3-6) were investigated. Results: Ninety-six of the 292 (33%) patients screened had ND. The mean age was 69.5 years; 62.5% were male and 65.6% were black. Patients with a poor functional outcome had significantly higher leukocyte and neutrophil levels 1 day before ND (P = .048 and P = .026, respectively), and on the day of ND (P = .013 and P = .007, respectively), compared to patients with good functional outcome.

Group B: Resection of maxilla without any preprosthetic surgical preparation. Forty-two Selleckchem GF120918 cancer patients (28 male-14 female).

Results: Outcome variables measured included facial contour and aesthetic results, speech understandability,

ability to eat solid foods, oronasal separation, socializing outside the home, and return-to-work status. Flap success and donor site morbidity were also studied.

Conclusions: To improve the prosthetic restoration of maxillary defect resulting maxillary resection as part treatment of maxillofacial tumor depends on the close cooperation between prosthodontist and surgeon, by combination of pre-prosthetic surgery during maxillectomy and prosthodontic technique.”
“Purpose To Selleckchem BI2536 describe a case of an orbito-nasal cyst in a cat.

Procedure An 18-month-old male European short-haired cat was presented to the Ophthalmology service of the Vetsuisse Faculty, University of Zurich for a subcutaneous swelling in the medial canthal region of the right eye (OD). Ophthalmologic, ultrasound and CT examinations, and fine needle aspiration were performed. After lesion excision, the removed tissue was submitted for histopathology. CT examination

was repeated 5 months after removal of the cyst.

Results Ophthalmologic examination revealed a large fluctuant swelling inferonasal to OD. Despite patent lacrimal puncta, only the first few mm of the lacrimal canaliculi could be cannulated. A normal globe with moderate enophthalmos was present. Ultrasound examination showed a well-defined lobulated cyst-like structure in the right orbit, inferonasal and anterior to the eye. CT examination revealed extension of this lesion through the medial LOXO-101 orbital wall into the right nasal cavity. Fine needle aspiration confirmed the cystic nature of the lesion. An orbito-nasal cyst was diagnosed. The orbital part of the cyst was dissected from the surrounding tissue and excised

from the periosteum in the medial orbital wall defect. Part of the maxillary bone was removed to allow removal of the cyst from the nasal cavity. Histologically, the cyst wall consisted of a single to multilayered, mostly cuboidal epithelium and surrounding connective tissue. Follow-up revealed a good functional result and no recurrence 7 months after cyst removal.

Conclusions Similar orbito-nasal cystic structures were reported in dogs but not in cats.”
“A new drimane sesquiterpenoid glycoside, named 7-drimen-3,11-diol 3-O–d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines.

Isoform analysis of beta-1,3-glucanase from the apoplastic fluid revealed that resistance was associated with the accumulation of an endo-beta-1,3-glucanase, previously implicated in defence against pathogens, and a protein with identity to ADPG pyrophosphatase (92%) and germin-like proteins (93%), which may be involved in cell wall reinforcement. In accordance with this, glycoproteins like extensin were released into the apoplast

and callose accumulated to a greater extent in cell walls, whereas lignin and polyphenolics were not found to correlate with defence. Treatment of a IPI-145 susceptible wheat cultivar with purified beta-1,3-glucan fragments from cell walls of S. tritici gave complete protection against disease and this was accompanied by increased gene expression of beta-1,3-glucanase and the deposition of callose. Collectively, these data indicate that resistance is dependent on a fast, initial recognition of the pathogen, probably due to beta-1,3-glucan in the fungal cell walls, and this results in the accumulation of beta-1,3-glucanase and structural defence responses, which may directly inhibit the pathogen and protect the host against fungal enzymes and toxins.”
“Introduction and hypothesis Our aim is to characterize prolapsed and non-prolapsed vaginal tissue, and thus offer buy Ro-3306 a better understanding of the genital prolapse physiopathology and

an improvement of surgical treatments.

Methods Vaginal tissue was collected in 30 patients with prolapse (POP) and ten fresh cadavers without prolapse (nPOP) with a favorable advice of Ethics Committee. Uniaxial tension tests were performed. Statistical comparisons of rigidity under moderate deformation and under large deformation have been performed

Results POP is significantly stiffer

than nPOP tissue, both on anterior and posterior walls. A significant difference between POP and nPOP tissues was highlighted when anterior or posterior vaginal walls were respectively compared.

Conclusions These results might explain the higher rate of relapse when repair is autologous, using already defective and more rigid Thiazovivin vaginal tissue. This study suggests that it might be interesting to adapt the characteristics of prosthetic implants to the vaginal face concerned by the prolapsus.”
“Objectives: Immune regulatory mechanisms may limit the immunopathologic condition of infection with Mycobacterium tuberculosis and suppress cellular immune responses in the host. We investigated the CD4(+)CD25(+)FoxP3(+) circulating regulatory T cells (T-reg) in patients with cavity multidrug-resistant tuberculosis (MDR-TB) before and after surgery.

Methods: We compared the proportion of T-reg cells in 13 patients with cavity MDR-TB pre- and postoperatively and in 10 healthy control subjects by flow cytometry using three specific markers in peripheral blood lymphocytes: cell-surface CD4 and CD25 expression and intracellular FoxP3 expression.

Median age was 57 years and 29 patients out of 31 had visceral involvement. The overall response rate (ORR) was 32% (1 complete response /9 partial responses), in addition 5 patients obtained stable disease

for >= 12 weeks. After a median follow-up of 34 months, all patients progressed with a median time to progression of 5.5 months and median overall survival of 11 months. Dose reductions, delays and omissions occurred in 75 (60%), 36 (29%) and 22 (18%) cycles. Grade 3/4 neutropenia occurred in 17 and febrile neutropenia in 4 patients. Ten selleck chemical patients had Grade 3/4 thrombocytopenia. Non hematological toxicities were manageable. The CG combination is a reasonable option for the treatment of metastatic pretreated TNBC patients.”
“Background: The term total folate intake is used to represent folate that occurs naturally in food as well as folic acid from fortified foods and dietary supplements. Folic acid has been referred to as a double-edged sword because of its beneficial role in the prevention of neural tube defects and yet possible deleterious ERK inhibitor effects on certain cancers and cognitive function. Previous monitoring efforts did not include folic acid from dietary supplements

and are therefore not complete.

Objective: Our objective was to combine data on dietary folate (as measured by two 24-h recalls) and folic acid from dietary supplements (collected with a 30-d frequency questionnaire) with the use of the bias-corrected best power method

to adjust for within-person variability.

Design: The National Health and Nutrition Examination Survey (NHANES) is a nationally representative, cross-sectional survey. Linear contrasts were constructed to determine differences in dietary and total folate intake for age and racial-ethnic groups by sex; prevalence of inadequate and excessive intakes is presented.

Results: In 2003-2006, 53% of the US population used dietary supplements; 34.5% used dietary supplements GSI-IX that contained folic acid. Total folate intake (in dietary folate equivalents) was higher for men (813 +/- 14) than for women (724 +/- 16) and higher for non-Hispanic whites (827 +/- 19) than for Mexican Americans (615 +/- 11) and non-Hispanic blacks (597 +/- 12); 29% of non-Hispanic black women had inadequate intakes. Total folate and folic acid intakes are highest for those aged > 50 y, and 5% exceed the Tolerable Upper Intake Level.

Conclusions: Improved total folate intake is warranted in targeted subgroups, which include women of childbearing age and non-Hispanic black women, whereas other population groups are at risk of excessive intake. Am J Clin Nutr 2010;91:231-7.”
“We successfully measured not only the tunneling properties but also the magnetic properties of a magnetic tunnel junction without patterning the magnetic tunnel junction stack itself by the current-in-plane tunneling method.

The association between TST induration and clinical outcome was assessed. The clinical utility of chest radiographs was evaluated.

Results: There was no difference in age, birth country, or nutritional status between

IAC with TST induration of 0 to < 5 mm and those with 5 to < 10 mm; IAC with TST >= 10 mm were older, more chronically malnourished, and more likely to emigrate from Guatemala. Among children with TST >= 5 mm (35%), 4 IAC had chest radiographs which were initially interpreted to be abnormal and consistent with TB; ultimately none were diagnosed with TB.

Conclusions: The 5-mm TST cut point did not capture IAC with risk factors for latent TB infection or progression to TB disease, suggesting that this buy GSK461364 is not a useful screening threshold. In contrast, a 10-mm cut point identified IAC at risk for TB infection and therefore should be a more useful screening MDV3100 supplier threshold. We question the clinical utility of radiographic screening for pulmonary TB in asymptomatic children.”
“The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine

the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida. The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.2% vs. Selleckchem LY2835219 22.7%). Multivariate analysis confirmed

that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality (beta coefficient = -0.3856; 95% confidence interval = -0.648 to -0.123).”
“In this study, Fe2O3.Al2O3/polyethylene composites were prepared using a two-step process. In the first step, PE is synthesized using titanium based metallocene catalyst system. While the synthesized PE was subsequently purified, hydrated alumina filled PE (MHFP) composites was formed by the hydrolysis of methylaluminoxane (MAO). In the second step, Fe2O3.Al2O3/PE was prepared via thermal decomposition of ferric formate in a high temperature solution of MHFP composite. The structure, morphology, and thermal properties of the composites were characterized using the XRD, FTIR, SEM-EDX, TGA, and DSC analytical techniques. Results showed that the incorporation of a suitable amount of Fe2O3.Al2O3 into the composites enhances the thermal stability. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011″
“Study Design. Retrospective case series.

Objective. The purpose of this study was to report on a large consecutive series of posterolateral fusion cases using rhBMP-2/ACS.

Summary of Background Data.

They did not show any distinguishing features except for the morphology in trichotillomania, which included twisted, linear (zip), and button-like pigment aggregation. The linear BAY 80-6946 PI3K/Akt/mTOR inhibitor arrangement was found also in friction alopecia and dissecting cellulitis. Pigmented casts in the hair canals of miniaturized/vellus hairs was a clue to alopecia areata. Pigmented casts can be observed in biopsies of different hair disorders, but they are not specific for the diagnosis. Horizontal sections allow to better assess their morphology and the follicular level of presence of pigmented casts, which in the context of the other follicular findings may be a clue to the diagnosis.”
“Background.

Due to the higher prevalence of obesity and diabetes mellitus (DM), more pregnant women complicated with diabetes are in need of clinical care. Purpose. Compare the effect of including only low glycemic index (GI) carbohydrates (CHO) against all types of CHO on maternal glycemic control and on the maternal and newborn’s nutritional status of women with type 2 DM and gestational diabetes mellitus ALK phosphorylation (GDM). Methods.

Women (n = 107, <= 29 weeks of gestation) were randomly assigned to one of two nutrition intervention groups: moderate energy and CHO restriction (Group 1: all types of CHO, Group 2: low GI foods). Results. No baseline differences in clinical data were observed. Capillary glucose concentrations throughout pregnancy were similar between groups. Fewer women in Group 2 exceeded weight gain recommendations. Higher risk of prematurity was observed in women in Group 2. No differences in glycemic control were observed between women with type Dactolisib 2 DM and those with GDM. Conclusions. Inclusion of low GI CHO as part of a comprehensive nutrition intervention is equally effective in improving glycemic control as compared to all types of CHO. This strategy had a positive effect in preventing excessive maternal weight gain but increased the risk

of prematurity.”
“Objective: To assess the character and frequency of fear of progression (FoP) and to clarify its relationship with cancer-related intrusive cognitions in breast cancer survivors.

Methods: A sample of 1083 patients was recruited in this cross-sectional study through a population-based Cancer Registry an average of 47 month following diagnosis (66% response rate). Participants completed self-report measures assessing fear of cancer progression (FoP-Q-SF), posttraumatic stress-disorder symptoms (PCL-C), coping strategies (DWI) and quality of life (QoL) (SF-8).

Results: In total, 23.6% of women were classified as having moderate to high FoP. Being nervous prior to doctors’ appointments or examinations and being afraid of relying on strangers for activities of daily living were the most frequent fears. FoP was significantly associated with younger age, having children, disease progress, chemotherapy, perceived amount of impairments, physical and mental QoL, but not with time since initial diagnosis.

Our transmission electron microscopy investigations revealed that the morphology of the blends was strongly influenced by the asymmetric nature of the interface between PA6 and ABS. In the blends with a PA6 matrix, the interface between PA6 and the ABS inclusions was deformed in tensile deformation under uniaxial loading. A strong influence of the PA6

water content on the (micro)mechanical behavior was observed. Although the “”dry”" blends behaved in a brittle fashion, the “”wet”" blends behaved in a ductile fashion with the formation of deformation bands in the matrix (PA6 or ABS), which were initiated by stress concentration at the particles (ABS or PA6, respectively). (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112:1658-1669, 2009″
“Objective-To compare the effect of xylazine GSK621 clinical trial bolus versus medetomidine constant rate infusion (MCRI) on serum cortisol and glucose concentrations, urine production, and anesthetic recovery characteristics in AZD6244 research buy dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses.

Design-Prospective, randomized crossover study.

Animals-10 healthy Standardbreds.

Procedures-Horses were premedicated with xylazine or medetomidine IV Anesthesia was induced with

diazepam and ketamine and maintained with isoflurane for 150 minutes. For the xylazine treatment, end-tidal isoflurane concentration was maintained at 1.7% and xylazine (0.2 mg/kg [0.09 mg/lb]), IV) was administered as a bolus at the end of anesthesia. For the MCRI treatment, end-tidal isoflurane concentration was maintained at 1.4% and medetomidine (0.005 mg/kg/h

[0.0023 mg/lb/h], IV) was infused throughout anesthesia. selleck products Serum cortisol and glucose concentrations were measured before, during, and after anesthesia. Urine specific gravity and volume were measured during anesthesia. Unassisted anesthetic recoveries were recorded by a digital video camera for later evaluation by 2 observers who were blinded to treatment.

Results-Serum cortisol concentration was lower and serum glucose concentration was higher with MCRI treatment, compared with xylazine treatment. Time to sternal recumbency was longer with MCRI treatment, but no difference was seen between treatments for times to extubation, first movement, or standing. Objective (mean attempt interval) and subjective (visual analog score) recovery scores were significantly better with MCRI treatment, compared with xylazine treatment.

Conclusions and Clinical Relevance-In isoflurane-anesthetized horses, premedication and administration of medetomidine as a constant rate infusion resulted in decreased serum cortisol concentration, increased serum glucose concentration, and superior anesthetic recovery characteristics, compared with conventional treatment with xylazine. (J Am Vet Med Assoc 2012;240:998-1002)”
“Here we approximate the plasma kinetics responsible for diamondlike carbon (DLC) depositions that result from pulsed-dc discharges.

Conclusions: Our study exemplifies the particularity of RF in young children and the complex role of superantigens and streptodornases in GAS-related pathologies. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Objective. Impacted canines require a combination PI3K inhibitor of both surgical and orthodontic management. In this study, patients treated for bone-impacted canines of the hard palatal were evaluated to assess which radiographic factors influenced the feasibility to move impacted maxillary permanent canines from the hard palate into the alveolar arch.

Materials and methods.

Eighty patients aged 12 to 24 (average 16 years) were treated surgically and orthodontically to align 146 bone-impacted canines of the hard palate (from 1994 to 2008). Factors such as age, sex, angulation of the canine to the midline (CAM), anomaly of the canine root (RA), overlap of the adjacent lateral incisor root (OALIR), and ratio of root formation (RRF) upon treatment were documented. Radiographic records and demographic data were assessed. The following radiographic measurements of canine position were made from the orthopantomogram (OPG): (1) angulation to the midline, (2) anteroposterior position selleck compound of the root, (3) overlap of the adjacent incisor. RA

or dilaceration was assessed from the OPG, maxillary occlusal (MO), and periapical (PA) radiographs. Whether the impacted canine had responded to surgical exposure and was orthodontically aligned, or surgically removed Microtubule Associat inhibitor and discarded was also recorded. The data were analyzed to assess and correlate significance.

Results. Eighty patients aged 12 to 24 (19 males and 61 females) with 146 bone-impacted permanent canines of the hard palatal were treated. One hundred and three teeth (70.54%) had responded to surgical exposure and orthodontic alignment within 9 to 12 months. Forty-three impacted canine teeth (29.46%) had to be surgically removed because

of ankylosis and no movement after 8 to 9 months using 50 to 60 g of traction force via elastic chains. Data analysis via chi-square and Pearson correlation tests showed that as the CAM increased (> 45 degrees), the canine was more likely to be unresponsive to treatment (P < .001). Increased overlap (> half the root) of the adjacent lateral incisor root (OALIR) via the canine crown influenced the treatment results negatively (P < .001). Additionally, presence of RA was also negatively influential (P < .001). However, the anteroposterior position of the canine did not influence the treatment results significantly, neither did age, sex, nor amount of root formation.

Conclusion.