Here we investigated the source of this effect with functional ma

Here we investigated the source of this effect with functional magnetic resonance imaging. find more Consistent with our predictions, we found that 1) feedback encountered in the maze task activated right parahippocampal cortex (PHC), 2) right PHC was

more activated by rewards following right turns compared to left turns in the maze, and 3) the rightward-biased activation was more pronounced in individuals who displayed good spatial abilities. These findings support our previous electrophysiological findings and highlight, in humans, a role for PHC theta oscillations in encoding salient information for the purpose of spatial navigation.”
“Combining antiresorptive and anabolic drugs for osteoporosis may be a useful strategy to prevent hip fractures. Previous studies comparing the effects of alendronate

(ALN) and teriparatide (TPTD) alone, combined or sequentially using quantitative computed GSK2126458 ic50 tomography (QCT) in postmenopausal women have not distinguished cortical bone mineral density (CBMD) from cortical thickness (CTh) effects, nor assessed the distribution and extent of more localized changes. In this study a validated bone mapping technique was used to examine the cortical and endocortical trabecular changes in the proximal femur resulting from an 18-month course of ALN or TPTD. Using Go 6983 chemical structure QCT data from a different clinical trial, the global and localized changes seen following a switch to TPTD after an 18-month ALN treatment or adding TPTD to the ALN treatment were compared. Ct.Th increased (4.8%, p smaller than 0.01) and CBMD decreased (-4.5%, p smaller than 0.01) in the TPTD group compared to no significant change in the ALN group. A large

Ct.Th increase could be seen for the switch group (2.8%, p smaller than 0.01) compared to a significantly smaller increase for the add group (1.5%, p smaller than 0.01). CBMD decreased significantly for the switch group (-3.9%, p smaller than 0.01) and was significantly different from no significant change in the add group. Ct.Th increases were shown to be significantly greater for the switch group compared to the add group at the load bearing regions. This study provides new insights into the effects of ALN and TPTD combination therapies on the cortex of the proximal femur and supports the hypothesis of an increased bone remodeling by TPTD being mitigated by ALN. (c) 2014 American Society for Bone and Mineral Research.”
“The development of arrays of human proteins has been a huge boon to the search for autoantibody diagnostics. Typically, slides with thousands of recombinant human proteins arrayed in an addressable fashion are incubated with sera from diseased or normal people.

Prospective studies on the CVR associated with arginine/ADMA rati

Prospective studies on the CVR associated with arginine/ADMA ratio and homoarginine in patients with moderate chronic kidney disease (CKD) are still scarce. We have studied how arginine, homoarginine and dimethylated arginine can predict cardiovascular events in such a population. Design and methods: We measured plasma concentrations of arginine (P-arginine), ADMA (P-ADMA), SDMA (P-SDMA), homoarginine (P-homoarginine) and other covariates

in 160 patients with predialytic CKD (mean age 57 years and mean eGFR 43 mL/min/1.73 m(2)) and followed them for 58 months in median. The risks of fatal and non-fatal cardiovascular events associated with the predictors were evaluated with multivariable Cox proportional hazard analysis. Results: There were 31 cardiovascular events during the observation period. In a multivariable model adjusted for age, sex, previous cardiovascular disease, P-cystatin C and Bucladesine solubility dmso P-homoarginine, the hazard ratio (HR) associated with an increase in arginine/ADMA ratio by 10 was 0.83 (P = 0.03). The HR of a 1 mu mol/L increase in P-homoarginine in the same model was 1.78 (P = 0.01). A statistically significant interaction between P-homoarginine and P-cystatin

C was found in an extended multivariable model. P-SDMA was not associated with increased CVR after adjustment for basic covariates. Conclusion: This study demonstrates a negative association between arginine/ADMA ratio and CVR in CKD patients and a positive association between P-homoarginine and CVR. The latter is in contrast to what has been demonstrated find more by others. (C) 2015

The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.”
“Complexes of platinum(II) with polypyridine (that is, the multidentate ligands related to pyridine, such as bipyridine GDC973 or terpyridine) have rich photophysical properties. These compounds are able to give different crystal forms in the solid state: this polymorphism is evident in the broad range of colors that can be observed in solid samples. Because of the square-planar coordination geometry of the metal center, Pt center dot center dot center dot Pt as well as pi-pi interactions between the chromophoric polypyridyl platinum(II) moieties are thought to contribute to the polymorphism. Owing to limited solubility, metal center dot center dot center dot metal interactions in platinum(II) polypyridyl systems had been mainly studied in the solid state, but our preparation of more soluble complexes has enabled detailed spectroscopic examinations in solution. In this Account, we describe our development of these alkynylplatinum(II) terpyridyl complexes and their unique spectral properties.\n\nA series of square-planar platinum(II) terpyridyl complexes with enhanced solubility due to the presence of the alkynyl group exhibited intense emission in solution.

In the present study, we investigated the protective effect of me

In the present study, we investigated the protective effect of melatonin against oxygen-glucose

deprivation, followed by reperfusion-(OGD/R-) induced injury, in bEnd.3 cells. The effect of melatonin was examined by western blot analysis, cell viability assays, measurement of intracellular reactive oxygen species (ROS), and immunocytochemistry (ICC). Our results showed that treatment with melatonin prevents cell death and degradation of tight junction protein in the setting of OGD/R-induced injury. In response to OGD/R injury of bEnd.3 cells, melatonin activates Akt, which promotes cell survival, and attenuates phosphorylation Nocodazole of JNK, which triggers apoptosis. Thus, melatonin protects bEnd.3 cells against

OGD/R-induced injury.”
“BackgroundPathologic extracapsular extension (pECE) in metastatic lymph nodes is associated with poor prognosis for oropharyngeal carcinoma. The prognostic value of radiographic extracapsular extension (rECE) has not been studied. MethodsA retrospective analysis was conducted of 111 patients with locally advanced oropharyngeal carcinoma treated in the Mount Sinai Radiation Oncology Department with accessible pretreatment CT reports. Univariate Kaplan-Meier and multivariate Cox regression analyses compared cohorts for locoregional control, distant control, progression-free (PFS), and overall survival (OS). ResultsSixty-four patients had rECE-present and 47 had rECE-absent scans. The patients with Nutlin-3 price rECE presence had significantly worse OS (3-year: 95% vs 77%; p = .006), PFS (3-year: 91% vs 71%; p = .002), and distant control (3-year: 98% vs 81%; p

= .008), with no difference in locoregional control. On multivariate analysis, rECE-presence was a negative prognosticator for OS, PFS, and distant control. ConclusionThis BVD-523 research buy study suggests that rECE is an independent prognosticator of poor distant control and survival with little impact on locoregional control for oropharyngeal carcinoma. (c) 2014 Wiley Periodicals, Inc. Head Neck 36: 1689-1694, 2014″
“Historically, the brainstem has been neglected as a part of the brain involved in language processing. We review recent evidence of language-dependent effects in pitch processing based on comparisons of native vs. nonnative speakers of a tonal language from electrophysiological recordings in the auditory brainstem. We argue that there is enhancing of linguistically-relevant pitch dimensions or features well before the auditory signal reaches the cerebral cortex. We propose that long-term experience with a tone language sharpens the tuning characteristics of neurons along the pitch axis with enhanced sensitivity to linguistically-relevant, rapidly changing sections of pitch contours.

Thirty-nine additional blind-coded Bartonella strains were correc

Thirty-nine additional blind-coded Bartonella strains were correctly identified at the species level,

including 36 with a significant score. Altogether, these data demonstrate that MS is an accurate and reproducible tool for rapid GDC-0973 and inexpensive identification of Bartonella species.”
“We have studied the dynamic scanning of liquid-crystalline (LC) poly(p-phenyleneterephthalamide) sulfuric acid (PPTA-H(2)SO(4)) solution, and its blend with single-walled carbon nanotubes (SWNTs), by using a flat plate rotational rheometer. The effects of weight concentration and molecular weight of PPTA, as well as operating temperature, on dynamic viscoelasticity of the PPTA-H(2)SO(4) LC solution system are discussed. The transition from a biphasic system to a single-phase LC occurs in the weight concentration range of SWNTs from 0.1% to 0.2%, in which complex viscosity reaches the maximum at 0.2 wt% and the minimum Pitavastatin order at 0.1 wt%, respectively, of SWNTs. With increasing SWNT weight concentration, the endothermic peak temperature increases from 73.6 to 79.9 degrees C. The PPTA/SWNT/H(2)SO(4) solution is in its plateau zone and storage modulus (G’) is a dominant factor within the frequency (omega) range of 0.1-10 rad/s. As omega increases, the G’ rises slightly, in direct proportion to the omega. The loss modulus (G ”) does not rise as a function of omega when omega < 1 s(-1), then when omega > 1 s(-1) G ” increases faster than

G’, yet not in any proportion to the omega.”
“Background: Dengue fever is the most important vector-borne viral disease. Four serotypes of dengue virus, DENV1 to DENV4, coexist. Infection by one serotype elicits long-lasting immunity to that serotype but not the other three. Subsequent infection by a different serotype is a risk factor for severe dengue. Domain III (ED3) of the viral envelope protein interacts with

cell receptors and contains epitopes recognized by neutralizing antibodies. We determined the serotype specificity and cross-reactivity of human IgMs directed against ED3 by using a well-characterized collection of 90 DENV-infected and 89 DENV-uninfected human serums.\n\nMethods: The recognitions between the four serotypes of ED3 and the serums were assayed with an IgM antibody-capture ELISA (MAC-ELISA) and artificial homodimeric antigens. The results were analyzed with INCB024360 datasheet Receiving Operator Characteristic (ROC) curves.\n\nResults: The DENV-infected serums contained IgMs that reacted with one or several ED3 serotypes. The discrimination by ED3 between serums infected by the homotypic DENV and uninfected serums varied with the serotype in the decreasing order DENV1 > DENV2 > DENV3 > DENV4. The ED3 domain of DENV1 gave the highest discrimination between DENV-infected and DENV-uninfected serums, whatever the infecting serotype, and thus behaved like a universal ED3 domain for the detection of IgMs against DENV.

DAPG enhanced expression

DAPG enhanced expression GSI-IX of a wide range of Sp245-Rif genes, including

genes involved in phytostimulation. Four of them (i.e., ppdC, flgE, nirK, and nifX-nifB) tended to be upregulated on roots in the presence of P fluorescens F113 compared with its phl-negative mutant. Our results indicate that DAPG can act as a signal by which some beneficial pseudomonads may stimulate plant-beneficial activities of Azospirillum PGPR.”
“Background\n\nPosttransplant lymphoproliferative disorder (PTLPD) is a relatively common complication in kidney transplant recipients. It. can involve the kidney allograft itself as well as extragraft sites. It is usually suspected clinically and diagnosed by tissue biopsy. It comprises a spectrum of lesions ranging from lymphoid hyperplasia to PP2 in vitro frank lymphoma.\n\nCase\n\nA 21-year-old male presented with recurrent episodes of microhematuria 2 years after a renal transplant. Voided urine cytology showed anaplastic, discohesive cells. Immunohistochemistry study on a urine cytospin showed the cells to be positive for LCA, CD20 and for CD 79a and negative for CD3, CD15, CD30, cytokeratin, S-100 and HMB45, confirming their lymphoid origin.\n\nConclusion\n\nThis is a rare suspected occurrence of PTLPD in voided urine. The presumptive diagnosis was supported by immunohistochemistry.

However, voided urine cytology should not be considered a standard diagnostic test due to its low sensitivity. Diagnosis and proper subclassification of kidney, PTLPD should be confirmed by histologic tissue study with supportive ancillary studies-e.g., immunohistochemistry and flaw cytometry. (Acta Cytol 2010;54:221-224)”
“Acrokeratosis paraneoplastica Bazex is a rare, obligate paraneoplasia initially presenting with palmoplantar hyperkeratosis. Later stages show acral psoriasiform lesions on other parts of the body. Common associated malignancies are laryngeal cancer and other tumors

of the head or neck region or neck lymph node metastases. A 49-year-old woman presented with palmoplantar hyperkeratoses for 4 months; in addition she had a squamous cell carcinoma of the larynx. We diagnosed a minor form of acrokeratosis BTSA1 chemical structure paraneoplastica Bazex. Some authors consider this as a separate entity, but the well- known course argues against this hypothesis. We report a case and review the literature.”
“P>Reasons for performing study:\n\nAnecdotal evidence collected by a variety of organisations has highlighted poor welfare in horses transported long distances to slaughter within the European Union.\n\nObjective:\n\nTo investigate welfare of horses being transported long distances within the EU to slaughter.\n\nMethods:\n\nData on transported horses were recorded at 2 assembly centres in Romania and at 4 abattoirs in Italy over an 8 month period in 2008.

Multitag pyrosequencing (MTPS) was performed on stool of cirrhoti

Multitag pyrosequencing (MTPS) was performed on stool of cirrhotics and age-matched controls. Cirrhotics with/without HE underwent cognitive testing, inflammatory cytokines, and endotoxin analysis.

Patients with HE were compared with those without HE using a correlation-network analysis. A select group of patients with HE (n = 7) on lactulose underwent stool MTPS before and after lactulose withdrawal over 14 days. Twenty-five patients [17 HE (all on lactulose, 6 also on rifaximin) and 8 without HE, age 56 +/- 6 yr, model for end-stage liver disease score 16 +/- 6] and ten controls were included. Fecal microbiota in cirrhotics were significantly Tipifarnib different (higher Enterobacteriaceae, Alcaligeneceae, and Fusobacteriaceae and lower Ruminococcaceae and Lachnospiraceae) compared with controls. We found altered flora (higher Veillonellaceae), poor cognition, endotoxemia, and inflammation (IL-6, TNF-alpha, IL-2,

and IL-13) in HE compared with cirrhotics without HE. In the cirrhosis group, Alcaligeneceae and Porphyromonadaceae were positively correlated with cognitive impairment. Fusobacteriaceae, Veillonellaceae, and Enterobacteriaceae were positively and Ruminococcaceae negatively related to inflammation. Network-analysis comparison showed robust correlations (all P < Epigenetic inhibitor cost 1E-5) only in the HE group between the microbiome, cognition, and IL-23, IL-2, and IL-13. Lactulose withdrawal did not change the microbiome significantly beyond Fecalibacterium reduction. We concluded that cirrhosis, especially when complicated with HE, is associated with significant alterations in the stool microbiome compared with healthy individuals. Specific bacterial families (Alcaligeneceae, Porphyromonadaceae, LDN-193189 cell line Enterobacteriaceae) are strongly associated with cognition and inflammation in HE.”
“Disease progression in myeloid malignancies results from the accumulation of “mutations” in genes that control cellular growth and differentiation. Many types of genetic alterations have been identified in myeloid diseases. However, the mechanism(s) by which these cells acquire genetic

alterations or “Genomic instability”, is less well understood. Increasing evidence suggests that the genetic changes in myeloid malignancies lead to increased production of endogenous sources of DNA damage, such as, reactive oxygen species (ROS). The fusion gene BCR-ABL in chronic myeloid leukemia (CML), FLT3/ITD in acute myeloid leukemia (AML), and RAS mutations in myelodysplastic syndromes (MDS)/myeloproliferative diseases (MPD) result in ROS production. Increased ROS can drive a cycle of genomic instability leading to DNA double strand breaks (DSBs) and altered repair that can lead to acquisition of genomic changes. Evidence is coming to light that defects in a main repair pathway for DSBs, non-homologous end-joining (NHEJ), lead to up-regulation of alternative or “back-up” repair that can create chromosomal deletions and translocations.

The patients were selected according to the haplotypes of ABCB1,

The patients were selected according to the haplotypes of ABCB1, with c.1236C>T, c.3435C>T and c.2677G>T polymorphisms, and were classified into two groups based on the presence of the mutated allele in each genotype for the three ABCB1 polymorphisms.

In addition, expression of P-gp and breakpoint cluster region-abelson 1 (BCR-ABL1), ABCB1 and solute carrier family 22 member 1 (SLC22A1) mRNA were evaluated. The P-gp activity in the wild-type group was found to be higher than that in the mutated group (59.1 vs. 38.3%; P=0.001). Furthermore, the patients who did not achieve major molecular response (MMR) showed a higher rate of efflux mediated by P-gp when compared with individuals who achieved MMR (64.7 vs. 45.7%; P=0.001). All patients without MMR demonstrated effluxes of >60%. In addition, patients without MMR exhibited lower plasma concentrations of IM compared with those with buy NVP-BSK805 MMR (0.51 vs. 1.42 mu g/ml; P=0.001). Higher levels of SLC22A1 mRNA were observed AZD8055 PI3K/Akt/mTOR inhibitor in patients who achieved MMR and complete molecular response (P<0.05). In conclusion, the ABCB1 1236CT/3435CT/2677GT and 1236TT/3435TT/2677TT haplotypes are associated with reduced P-gp activity and MMR in chronic-phase CML patients treated with a standard dose of IM.”
“Objective: There is a paucity of evidence about insurance status and the likelihood of receiving medical services in Latin America. The objective

of this analysis was to examine the association between insurance status and pharmacologic treatment for depression. Methods: Patients referred to a memory

clinic of a public hospital in Buenos Aires, Argentina, and identified with any of four types of depression (subsyndromal, dysthymia, major, and due to dementia) were included. Age, years of education, insurance status, Beck Depression Inventory score, and number of comorbidities were considered. Associations between these factors and not receiving pharmacologic treatment for depression were examined with logistic regression. Use of prescription neuroleptics, hypnotics, and anticholinesterase inhibitors was also explored. Results: Out of 100 patients, 92 learn more with insurance status data were used. Sixty-one patients (66%) had formal insurance and 31 patients (34%) lacked insurance. Twenty-seven (44%) insured patients and 23 (74%) uninsured patients did not receive antidepressants (P = 0.001). Controlling for other factors, uninsured patients had 7.12 higher odds of not receiving treatment compared to insured patients (95% confidence interval 1.88-28.86). Older patients and those with more comorbidities had higher odds of not receiving treatment. More educated patients, those with higher Beck Depression Inventory score, and those without subsyndromal depression had lower odds of not receiving treatment. None of those associations were statistically significant.

In addition, COPT6 interacts with itself and

with its hom

In addition, COPT6 interacts with itself and

with its homolog, COPT1, unlike Ctr1p, which interacts only with itself. Analyses of the expression pattern showed that although COPT6 is expressed in different cell types of different plant organs, the bulk of its expression is located in the vasculature. We also show that COPT6 expression is regulated by copper availability that, in part, is controlled by a master regulator of copper homeostasis, SPL7. Finally, studies using the A. thaliana copt6-1 mutant and plants overexpressing COPT6 revealed its essential role during copper limitation and excess.”
“A note about nomenclature: The ortholog of the gene mutated in rhabdoid tumors was first studied in yeast where it was identified in a screen for Vactosertib inhibitor mutants incapable of fermenting sucrose. It was thus given the name Sucrose Non-Fermenting gene number 5 (SNF5) and was subsequently found to be a member of the SWI/SNF chromatin remodeling complex. The human ortholog of the gene was identified in a screen for proteins capable of interacting with the integrase protein of the human immunodeficiency virus and was given the name INtegrase Interactor 1 (INI1).

Investigators studying a mammalian version of the Swi/Snf complex felt that its function may have diverged somewhat from the yeast complex and thus proposed renaming the complex the Brg1/Brm Associated Factors complex, or BAF complex. The rhabdoid tumor gene was thus given the name BAF47 based upon its apparent molecular mass

of 47 Kd. Most recently, the genetic nomenclature committee bestowed the name SMARCB1 for SWI/SNF related, BLZ945 Matrix associated, Actin dependent Regulator of Chromatin, subfamily B, member 1. Each of these names has been used extensively in the literature and we ourselves have referred to the gene as either SNF5 (CWMR) or INI1 (JAB). In an effort to simplify communication, we have chosen to use the official SMARCB1 nomenclature here.”
“Purpose Little research exists to indicate whether the general public can provide proxy health-related Selleck Sapanisertib quality-of-life (HRQoL) estimates for persons with Alzheimer’s disease (AD). We investigated (1) whether the general public can differentiate between mild, moderate, and severe AD and (2) whether the general public’s proxy HRQoL estimates are correlated with current health status.\n\nMethods We conducted computer-assisted personal interviews. The computer randomly assigned each participant to read a vignette describing mild, moderate, or severe AD. Participants answered the EQ-5D-5L and Quality-of-life-Alzheimer’s Disease (QoL-AD), while imagining living in the health state described in their assigned vignette. Participants also answered the EQ-5D-5L based on their health state at the time of the interview.\n\nResults We interviewed 100 participants. EQ-5D-5L utilities were 0.7413 (mild), 0.

Our results show that, due to inducible nitric oxide synthase up-

Our results show that, due to inducible nitric oxide synthase up-regulation, abcd3kd cell line produces higher levels of nitrites than native C6 cells. The enhanced production of superoxide and thiobarbituric acid-reactive substances, the increased expression of mitochondrial superoxide dismutase, and the reduction of catalase and glutathione peroxidase activities confirm the presence of an oxidative

process. We then measured the concentrations of TNF alpha, IFN gamma, and IL-12 and we observed that abcd3kd cells produce higher amounts of pro-inflammatory cytokines compared to native C6 cells. By using neutralizing antibodies against IL-12, not only inflammatory parameters significantly decrease, but nitrite and superoxide production is also affected. This demonstrates that oxidative status of abcd3kd cells is not a direct PMP70 selleck kinase inhibitor knock-down consequence, but depends on IL-12 release.\n\nThe scenery induced by the knock-down

of PMP70 in C6 cells recall the oxidative and inflammatory status observed in human X-ALD and thus reinforce the idea that PMP70 could affect the clinical course of the disease. (C) 2008 Elsevier Ltd. All rights reserved.”
“The moisture sorption isotherms of grain and kernel of barnyard millet (Echinochloa frumentacea) were determined at 20, 30, 40, and 50 A degrees C. A gravimetric static method was used under 0.112-0.964 water activity mTOR inhibitor (a (w)) range for the determination of sorption

isotherms. The models were compared using the coefficient Danusertib molecular weight of determination (r (2)), reduced chi-square (chi (2)) values, and on the basis of residual plots. In grain, modified Chung-Pfost (r (2) > 0.99; chi (2) < 0.7) and modified Oswin (r (2) > 0.99; chi (2) < 0.55) models were found suitable for predicting the M (e) -a (w) relationship for adsorption and desorption, respectively. Modified Henderson model was found to give the best fit (r (2) > 0.99 and chi (2) < 0.55) for describing the adsorption and desorption of the kernel. The isosteric heat, calculated using Clausius-Clapeyron equation, was varied between 46.76 and 61.71 kJ g(-1) mol(-1) at moisture levels 7-21% (d.b.) for grain and 47.11-63.52 kJ g(-1) mol(-1) at moisture level between 4% and 20% (d.b.) for kernel. The monolayer moisture content values ranged from 4.3% to 6% d.b. in the case of adsorption of barnyard millet grain and 5.2-6.6% d.b. in the case of desorption at the temperature ranges of 50-20 A degrees C. The monolayer moisture values of barnyard millet kernel ranged from 4.4% to 6.67% d.b. in adsorption and 4.6% to 7.3% d.b. in desorption in the temperature ranges of 50-20 A degrees C.

Three patients demonstrated a flaccid paresis, one patient had a

Three patients demonstrated a flaccid paresis, one patient had a psychogenic dystonia. Motor thresholds, short interval intracortical inhibition and intracortical facilitation recorded from the affected side were normal. In healthy subjects, movement imagination produced ail increase of corticospinal excitability. In the patients motor imagery with the affected index finger resulted in it decrease of corticospinal excitability compared to rest, being significantly different from the unaffected

side and from the control group. We suggest that suppression of corticospinal excitability during movement imagination is an electrophysiological correlate of the patients’ inability to move voluntarily and provides sonic insight into the pathophysiology

of this disorder. (C) 2008 Movement Disorder LY294002 Society”
“Objective. Our objective was to perform a retrospective study that described the anastomosis technique as well as the complications of side-to-side cavo-caval reconstruction.\n\nPatients and Methods. From June 1998 to April 2011, we performed 284 liver transplantations including 10 adults with live donor organs. In all cases but 2 (272), cavo-caval reconstruction was performed using side-to-side cavo-caval (STSCC) anastomosis. In 19 cases (6.9%), we also carried out an end-to-side temporary porto-caval shunt (TPCS). In 17 cases (6.2%) the technique was performed for retransplantation.\n\nResults. STSCC anastomosis Nepicastat was technically feasible in all https://www.selleckchem.com/products/BEZ235.html but 2 cases, regardless of the recipient’s vena cava, anatomic factors, or graft size. Mean operative time for the STSCC was 13 minutes (range, 6-25). Routine Doppler ultrasonography was performed intraoperatively at the end of the surgery. There was no case of cava stump thrombosis. Complications associated with this technique were limited to 2 patients. One complication was torsion due to donor graft/recipient mismatch, which was successfully treated

surgically by falciform ligament fixation. The second complication was only evident by sinusoidal congestion and was managed nonoperatively. Seventeen cases were uneventful for retransplant recipients.\n\nConclusions. STSCC during piggyback liver transplantation is safe and can be performed in the retransplantation setting, with a low incidence of venous outflow obstruction that can be associated with the traditional piggyback technique. Our data suggest that donor graft to recipient mismatch is not an absolute contraindication when proper body size match is considered. A wide anastomosis with typical recipient hepatic vein inclusion is warranted with routine postanastomotic Doppler ultrasonography.